INFLUENCE OF HAEMOGLOBIN GENOTYPE ON NORMAL BLOOD RHEOLOGY

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INFLUENCE OF HAEMOGLOBIN GENOTYPE ON NORMAL BLOOD RHEOLOGY

Abstract

This study investigates the influence of hemoglobin genotype on normal blood rheology, focusing on how different genotypes impact blood flow properties and overall hemodynamic function. Hemoglobin, a critical protein in red blood cells, exists in various genotypic forms, including normal (HbAA), sickle cell (HbAS), and other variants. We conducted a comprehensive analysis involving participants with different hemoglobin genotypes, measuring parameters such as blood viscosity, shear stress, and deformability of erythrocytes. Our findings reveal significant variations in blood rheological properties across genotypes, with HbAA exhibiting optimal flow characteristics compared to HbAS. These variations have implications for microcirculation and oxygen delivery, potentially affecting individuals’ health outcomes. Understanding these differences is crucial for developing targeted interventions and optimizing management strategies for conditions influenced by hemoglobin variants.

Table of Contents

Chapter 1: Introduction

1.1 Background of the Study

1.2 Statement of the Problem

1.3 Objectives of the Study

1.4 Research Questions

1.5 Significance of the Study

1.6 Scope and Limitations

Chapter 2: Literature Review

2.1 Overview of Hemoglobin Genotypes

2.2 Blood Rheology: Concepts and Importance

2.3 Influence of Hemoglobin Genotype on Blood Properties

2.4 Clinical Implications of Blood Rheology Variations

2.5 Summary of Key Findings from Previous Studies

Chapter 3: Methodology

3.1 Study Design

3.2 Study Population and Sample Size

3.3 Data Collection Methods

3.4 Laboratory Techniques for Rheological Analysis

3.5 Data Analysis Procedures

3.6 Ethical Considerations

Chapter 4: Results and Discussion

4.1 Presentation of Findings

4.2 Analysis of Hemoglobin Genotype Effects on Blood Rheology

4.3 Discussion of Results in Relation to Existing Literature

4.4 Implications of Findings for Clinical Practice

4.5 Limitations of the Study

Chapter 5: Conclusion and Recommendations

5.1 Summary of Key Findings

5.2 Conclusions Drawn from the Study

5.3 Recommendations for Future Research

5.4 Practical Applications of Research Findings

References

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