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THE EFFECT OF KAKA BITTERS ON THE LIPID PROFILE OFWISTAR RATS FED WITH HIGH FAT DIET
ABSTRACT
Analysis of well water sample was carried out using colorimetry method to determine the amount of fluoride in fieen
wells water samples in Iree metropolis of Boripe Local government area of Osun State, Nigeria. The problem of the study is that it was observed that some people living in the area of study are suering from skeletal deformation and dental fluorosis. This necessitates the study of the fluoride content of the well water in the area. The well water samples were
selected in different parts of Iree metropolis which are; Small London Zone, o
Campus Zone, B.H.S Zone, Oris Zone, Eyinade Zone, Oke-Aree Zone and Ladoja
Zone. From the results, Small London Zone (America Embassy) has 1.0mg/L, (Harmony Garden) has 1.5mg/L and (Sugar Boys Hall) has 0.94mg/L, O Campus Zone (Alternative Hall) has 0.75mg/L and (His Mercy Hall) has 1.0mg/L, B.H.S Zone (United Kingdom Hall) has 1.2mg/L and (David Liz Hostel) has 1.4mg/L, Oris Zone (Sobaloju Ayoni Hall) has 0.82mg/L, Eyinade Zone (Life International College) has 1.5mg/L, (Terminus Hall) has 0.98mg/L and (Cotonou Villa) has 1.0mg/L, Oke-Aree Zone (Yakoyo Food Centre) has 1.5mg/L, (Innovated hall) has 1.0mg/L and Ladoja Zone ( Feel at Home Hall) has 1.0mg/L and (New world Phase 4) has 0.95mg/L. It was discovered that some of the well water did not meet up with World Health Organization’s (WHO) standard for the amount of fluoride that should be present in a given portable water which is 1.0-1.5mg/l. From the findings some wells meet the World Health Organization’s (WHO) standard in which some did not. Hence, people living in the study area should analyze their wells before drinking and there should be public enlightenment to this regard.
CHAPTER ONE
1.0 INTRODUCTION
1.1 General Background
Fluoride is one of the very few chemicals that have been shown to cause significant eects
in people through drinking-water. Fluoride has beneficial effects on teeth at low concentrations in drinking-water, but excessive exposure to fluoride in drinking-water, or in combination with exposure to fluoride from other sources, can give rise to a number of adverse effects. These range from mild dental fluorosis to crippling skeletal fluorosis as the level and period of exposure increases. Crippling skeletal fluorosis is a significant cause of morbidity in a number of regions of the world (J. Fawell, K. Bailey, J. Chilton, E. Dahi, L. Fewtrell and Y. Magara 2006). Fluoride is known to occur at elevated concentrations in a number of parts of the world and in such circumstances can have, and oen has, a significant adverse impact on public health and well-being (J. Fawell, K. Bailey, J. Chilton, E. Dahi, L. Fewtrell and Y. Magara 2006).
There is now a continuing process of updating the (GDWQ) Guideline for Drinking Water Quality, through which it was concluded that there was a need for a monograph on fluoride in drinking-water that would be useful to a wide range of individuals, including health workers and sanitary engineers who may require a broad introduction to the subject, but would still provide more detailed guidance in some specific areas. Such a monograph could provide an appropriate introduction and background information, and indicate where other more detailed information could be obtained. The primary focus of the monograph is the prevention of adverse effects from excessive levels of fluoride in drinking-water.
Fluoride is found in all natural waters at some concentration. Seawater typically contains about 1mg l–1 while rivers and lakes generally exhibit concentrations of less than 0.5 mg l–1. In groundwater, however, low or high concentrations of fluoride can occur, depending on the nature of the rocks and the occurrence of fluoride-bearing minerals. Concentrations in water are limited by fluorite s. It is the absence of calcium in solution which allows higher concentrations to be stable (Edmunds and Smedley, 1996). Iree town which is the focus of this project work has a very high tendency for the presence of fluoride in its ground water because of the geological nature of the area. Iree is a town surrounded by dierent rocks and the presence of this rock naturally leads to the presence of fluoride in all the well water in Iree
metropolis. The problem that necessitated this project include dental fluorosis and skeletal deformation in some people living in Iree metropolis. This project is to determine the effect
and implication of fluoride on drinking well water in some areas in Iree community of Osun state, Nigeria.
1.2 Statement Of The Problem
The problem of the study is the health hazard noticeable among the inhabitants of the study areas such as dental fluorosis and skeletal deformation which
may be traceable to the amount of fluoride in well water.
1.3 Aims And Objectives Of The Study
1. To know the required dosage of fluoride needed in drinking well water.
2. To know the health implications of the amount of fluoride in drinking well water in Iree metropolis.
1.4 Significance of The Study
Fluoride has beneficial effects on teeth at low concentrations in drinking-water, but excessive exposure to fluoride in drinking-water, or in combination with exposure to fluoride from other sources, can give rise to a number of adverse eects
such as Dental fluorosis, and skeletal deformation.
1.5 Scope of the Study
This project work covers well water from O-campus,
Ladoja, Oke Aare, Small London, Oris, B.H.S, and Eyinade area of Iree metropolis.
1.6 Limitation of the Study
The project work could not cover the entire iree community for the following reason
1. Financial constraints.
2. Mobility.
3. Time constraints.
4. Lack of accessibility in some areas.
1.7 Definition Of Terms
EFFECT: This may refer to a result or change of something.
IMPLICATION: This is the conclusion that can be drawn from something, although it is not explicitly stated.
GDWQ: This is the acronym of Guideline for Drinking Water Quality.
FLOUROSIS: This is a condition due to the ingestion of excess amount of fluorine.
FLOURIDE: Fluoride is the anion of fluorine, it is also the reduced formed of fluorine.
FUMAROLIC GASES: This is a vent in the surface of the Earth from which hot smoke and gases escape.
FLUORIDATION: This is the controlled addition of fluoride to a public water supply to reduce tooth decay.
DENTAL FLUOROSIS: This is a change in the appearance of the tooth’s enamel.
ENDEMIC: This means a disease occurs frequently and at a predictable rate in a specific location or population.
ENAMEL: This is a vitreous, usually opaque, protective or decorative coating baked on metal, glass, or ceramic.
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